Dostinex Tablets Summary of Product Characteristics SmPC emc

Lower doses should be considered in patients with severe hepatic insufficiency who receive prolonged treatment with cabergoline. Compared to normal volunteers and those with lesser degrees of hepatic insufficiency, an increase in AUC has been seen in patients with severe hepatic insufficiency (Child-Pugh Class C) who received a single 1 mg dose. The recommended initial dosage of cabergoline is 0.5 mg per week given in one or two (one-half of one 0.5 mg tablet) doses (e.g. on Monday and Thursday) per week. The weekly dose should be increased gradually, preferably by adding 0.5 mg per week at monthly intervals until an optimal therapeutic response is achieved.

  • You should not take cabergoline with erythromycin or clarithromycin (these are types of antibiotics), as they increase the cabergoline level in the blood, increasing the risk of sideeffects.
  • Rebound breast symptomatology after day 10 is uncommon (approximately 2% of cases).
  • On the third day of admission, she experienced dyspnoea, orthopnoea and cough.
  • The response was excellent, with prolactin at 774mU/l and testosterone at 9.9nmol/l.

One message was dramatically different in tone, written in unnecessarily large, bold font. He reported feeling very well, ‘confident and full of energy’, and was letting me know of his plans for travel, and various interests he had taken up, all of which sounded cost-prohibitive. There was a sudden change in the frequency and nature of these calls.

Cabergoline EP Impurity C has long been used to treat prolactinomas for symptomatic, radiological and biochemical resolution of pituitary tumours. As clinicians we are well-versed at screening for physical side effects, but are we holistic enough? We present two cases illustrating the damaging social consequences of cabergoline treatment for prolactinomas. Under in-patient observation due to apoplexy risk, he started cabergoline. Ali and his family were counselled regarding cabergoline’s effects and potential side effects. Prolactin fell to 19,448mU/l following a single 500mg dose and he was discharged on 500mg twice weekly.

Inhibition of lactation

Of the group of women followed up, 23/29 had ovulatory cycles which continued for greater than 6 months after cabergoline discontinuation. For inhibition of lactation cabergoline should be administered during the first day post-partum. The recommended therapeutic dose is 1 mg (two 0.5 mg tablets) given as a single dose. Suppression of milk secretion and relief of breast engorgement and pain are obtained in approximately 85% of nursing women treated with a total dose of 1 mg cabergoline given in four divided doses over two days.

An MRI scan of his pituitary revealed a 11 × 9 mm pituitary adenoma. His prolactin fell from 2464 to 18 within 5 months, with testosterone levels of 18.9. In October 2019, his worried partner reported a change in personality and hypersexuality.

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